Lower extremity amputation in peripheral artery disease
Peripheral artery disease (PAD) of the lower extremity is most frequently manifested as intermittent claudiciation (pain on exertion, improving with rest.) Approximately 5% of persons with this symptom will progress to amputation within 5 years of onset. To reduce this statistic an effective care pathway is advised.
1: Improve recognition;
By practitioners and public; allowing early diagnoses and better foot management.
Geographical location currently dictates amputation decisions; a standardised pathway would prevent this.
3: Revascularization techniques;
There have been significant advancements in the last years; research is needed to validate these.
4: Novel therapies;
Proven atherosclerosis treatments are common in PAD treatment. However, have no effect on leg blood flow. Cell therapy and gene therapy must be expanded to provide specialised treatment.
Although there are many proposals to improve care for PAD the first step must be better understanding the best clinical practises and bridging gaps in the scientific evidence of the therapies available.