Ankle inversion sprains are reported as being the most commonly occurring sport related injury. Following recovery and rehabilitation it is often observed that inversion injuries will result in chronic ankle instability (CAI). Deficits in dorsiflexion are often associated with CAI and have been linked with recurrent sprains therefore manual therapy is commonly utilized to restore limitations in talocrural arthrokinematics. With this in mind, the current study compared the effects of mobilization with movement (MWM) and talocrural manipulation. Overall, it was shown that both techniques increase ankle dorsiflexion in patients with CAI with effects that last several days post treatment.