Medial tibial stress syndrome (MTSS) is one of the most frequently reported injuries in physically active populations. It is a common injury in runners and military personnel. Up until today it remains unclear what risk factors contribute to the development of MTSS. Nine risk factors were included in this paper. It was shown that a higher BMI, increased navicular drop, increased plantar flexion and increased external rotation of the hip are risk factors, significantly contributing to the onset of MTSS.