Neural root compression injuries are multi-factorial conditions that have been shown to accompany low back pain (LBP). They are often associated with structural alterations, neural ischemia and functional modifications of patients affected. Neurodynamic mobilisation (NMD) has been developed for clinical practice to normalize compressive, frictional and tensile forces commonly related to functional movement. Despite the clinical dissemination of NDM, the underlying mechanism for positive results following its application is unknown. With this in mind, the authors of the present study sought to assess the intraneural fluid dynamics in nerve roots with repetitive NDM. When performed on unembalmed cadavers, NDM was to shown to produce a significant increase in longitudinal fluid dispersion in lumbar nerve roots.