Pregabalin for neurogenic claudication
Neurogenic claudication is a common symptom of lumbar spinal stenosis. Symptoms include pain in the buttocks or legs induced by walking or prolonged standing. There is limited clinical evidence for either conservative treatment or surgery, with symptoms often recurring. The aim of this study was to test the effects of pregabalin on the induction of neurogenic claudication.
A total of 29 subjects were randomised to receive either pregabalin followed by active placebo (diphenhydramine) or active placebo followed by pregabalin. Each period lasted for 10 days with a 3 day taper period and separated by a 10-day washout period. No significant difference was found between pregabalin and active placebo in time to first moderate pain. No significant differences were found for any of the other outcome measures including distance walked on a treadmill and patient-reported outcome measures of pain.
The cost and burden of many treatments for chronic low back pain often require that the most common treatments are more effective and provide greater relief than placebo. Future clinical trials, that match therapeutic interventions associated with neurogenic claudication are needed to increase the feasibility to detect true treatment effects and evaluate conservative management.
> From: Markman et al., Neurology (2014) (Epub ahead of print). All rights reserved to American Academy of Neurology. Click here for the Pubmed summary.