Chronic non-specific low back pain (NSLBP) is one of the most common musculoskeletal related issues faced by therapists. Motor control exercise (MCE) is commonly utilized to help activate and coordinate the deep and global trunk muscles to mitigate symptoms and manage pain. The authors of the current study systematically investigated the most current literature to determine the efficacy of MCE on NSLBP. Overall, it was shown that, when compared to minimal intervention (control or sham), MCE had low evidence of a clinically important difference. When comparing MCE to exercise plus electrophysical agents there was minimal evidence and when comparing MCE to manual therapy there was moderate to high evidence that there was no clinically importance difference.